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Current Edition   

December 2016

Volume 3  Issue 2

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Review Article

Resolving Dimensions of Differential Tumorigenesis in Terms of Partial Differentiation and De-Differentiation of Proliferating Stem Cells and Progenitor Cells in the Central Nervous System

Lawrence M. Agius*

Distributional parameters as profile formulas of malignant transformation events indicate the outline attributes for further projection by the dynamics and spread of proliferating progenitor cells and within the contexts of primary and secondary stem cell microenvironments. Performance attributes are in themselves re-characterizations of the stem cell niches and of multi-potential or bi-potential subgroups of progenitor cells within the central nervous system. Promotional dynamics of partial differentiation of such cells determine the essential heterogeneity of stem cells and progenitor cells that influence quantitative dimensions of propagation and spread of transformed cells.

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Research Article

Change in Mood and Functional Outcomes in the Year following Subarachnoid Haemorrhage and Comparison to Matched Controls

Rebecca Nicholson, PhD, Suzanne Barker-Collo, PhD*, Valery Feigin, PhD for the ARCOS- study group

Subarachnoid Haemorrhage (SAH) research rarely examines psychological outcomes, particularly in relation to functional recovery (e.g., Health Related quality of life HRQoL). This study describes mood and functional outcomes in the first year post- SAH, compared to matched controls, and examined factors related to mood and function at 12-months. Thirty individuals with SAH and 29 age, gender and ethnicity matched controls participated. SAH-participants were assessed at 28-days, 6- and 12-months post-SAH on the Hospital Anxiety Depression Scale(HADS), General Health Questinonaire-28(GHQ-28), Short Form- 36(SF-36), modified Rankin Scale(mRS), and Barthel Index (BI).

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Short Report

An Acute Cerebellar Syndrome. Who Is Involved?

Salimata Gassama*, Damien Fetter, Xavier Monnet, Bertrand Bourre, Mathieu Chasta, David Maltête, Didier Hannequin, Nicolas Mirlink

A 79 year-old man was admitted to our Neurology Department in May 2015 for an acute cerebellar syndrome. He had history of alcoholism, alcoholic Child-Pugh C13 cirrhosis, psoriasis, systemic hyper-tension and hypercholesterolemia. Usual treatments were Aldactone 25mg/day and Oxazepam 20mg/ day. The patient was fully independent before this episode. He had slight gait disturbances that had never been explored and walked with a stick. His Instrumental Activities of Daily Living (IADL) score was 6/6.

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Case Report

Chronic Inflammatory Demyelinating Polyneuropathy Secondary to Hypereosinophilia: A Rare Case

Linli Zhou, Aimin Wu, Zhuoshan Huang, Zhengqi Lu, Chunkui Shao, Dongjun Lin, Xiaohong Chen*

A 16-year-old male with limb weakness, reduced muscle tone and absent reflexes was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) secondary to idiopathic hypereosinophilic syndrome (IHES). Oral corticosteroids decreased the eosinophil count but disease relapse and elevation of the eosinophil count occurred after the dose was tapered. However, organ dysfunction was responsive to intravenous immunoglobulin. The use of intravenous immunoglobulin for CIDP secondary to IHES has not been reported.

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