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September  2014

Volume 1 Issue 1
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Editorial

Dementia and Driving: A Modern Gordian Knot

John Carmody* and Victoria Traynor

Dementia refers to a syndrome characterised by a progressive deterioration of memory and at least one other cognitive domain (e.g. language, executive function, praxis) which interferes with one’s daily function and independence. Epidemiological data indicate the prevalence of dementia to be 6.5% of those aged over 65.                                                                                                                                                                                                                                                             Full textDownload PDF      

 

 

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Editorial

Mitochondria-Targeted Plastoquinone Antioxidant Skq1 Rescues Amyloid-Beta-Induced Impairment in Hippocampal Synaptic Plasticity

V. G. Skrebitsky

Mitochondria-targeted antioxidants SkQ1 and MitoQ are known to improve a number of pathologic disorders mediated by the reactive oxygen species (ROS) such as heart ischemia, stroke and Alzheimer’s disease. Evidence emerging from studies on aging and Alzheimer’s disease models shows that the harmful trio “aging, amyloid- β peptide (Aβ), and tau protein” triggers mitochondrial dysfunction.                                                                                             

                                                                                                                                                                                                                                  Full textDownload PDF          

 

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Research Article

Prevalence and Phenotype of Patients with PARK2 or PARK8 Gene Mutations in an Early-Onset Parkinsonism Brazilian Cohort

Delcio Bertucci Filho, Renato P. Munhoz, Suzanne Lesage, Alexis Brice, Salmo Raskin and Helio A. G. Teive

To estimate the prevalence of mutations in the PARK 2 or PARK 8 genes and characterize their phenotypes in a Brazilian cohort of early-onset Parkinsonism (EOP).                                                                 

                                                                                                                                                                                                                                  Full textDownload PDF

 

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Case Report
Recurrent Facial Baroparesis Occurring on Commercial Flights in The United States

William S Baek*

Facial baroparesis was first described in 1985 and refers to transient facial neurapraxia due to barotrauma. We report a case of recurrent facial baroparesis occurring during domestic flights. 

 

                                                                                                                                                                                                                                   Full text                     Download PDF         

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Review Article
CMT1A and T2DM versus CMT1A Alone: A Retrospective Comparison of Nerve Conduction Values and Terminal Latency Index

Andrew Lavigne and Steven K. Baker

To investigate the effects of concurrent Charcot-Marie-Tooth type 1A (CMT1A) and type 2 Diabetes mellitus (T2DM) on median nerve conduction parameters and terminal latency index.   

 

 

                                                                                                                                                                                                                                                         Full textDownload PDF        

 

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Research Article
Anemia and Cholesterol Level are Independently Associated with Anxiety and Depression  

Anna G. Polunina*, Renat G. Akzhigitov, Alexander A. Yakovlev ,Anna A. Gudkova, Alla B. Guekht, Elena V. Smirnova,Natalia V. Gulyaeva

Depression and anxiety are multifactorial neuropsychiatric conditions characterized by intensive negative emotionality along with autonomic and neuroendocrine dysfunction. 

 

                                                         Full textDownload PDF         

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Research Article
Envisioning PACAP-Based Therapy for Alzheimer’s Disease  

Pengcheng Han*, Jiong Shi, Mary T. Lucero

Alzheimer’s disease (AD) is the most common cause of dementia in elderly adults. With the growing number of people living to an older age, there is an urgency to better understand elements of the pathogenic pathway, discover agents that target these elements, and establish their roles in the treatment and prevention of AD. 

                                                                                                                                                                                                                                                               Full text Download PDF 

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