Volume 1 Issue 1
Dementia and Driving: A Modern Gordian Knot
John Carmody* and Victoria Traynor
Dementia refers to a syndrome characterised by a progressive deterioration of memory and at least one other cognitive domain (e.g. language, executive function, praxis) which interferes with one’s daily function and independence. Epidemiological data indicate the prevalence of dementia to be 6.5% of those aged over 65.
Mitochondria-Targeted Plastoquinone Antioxidant Skq1 Rescues Amyloid-Beta-Induced Impairment in Hippocampal Synaptic Plasticity
V. G. Skrebitsky
Mitochondria-targeted antioxidants SkQ1 and MitoQ are known to improve a number of pathologic disorders mediated by the reactive oxygen species (ROS) such as heart ischemia, stroke and Alzheimer’s disease. Evidence emerging from studies on aging and Alzheimer’s disease models shows that the harmful trio “aging, amyloid- β peptide (Aβ), and tau protein” triggers mitochondrial dysfunction.
Prevalence and Phenotype of Patients with PARK2 or PARK8 Gene Mutations in an Early-Onset Parkinsonism Brazilian Cohort
Delcio Bertucci Filho, Renato P. Munhoz, Suzanne Lesage, Alexis Brice, Salmo Raskin and Helio A. G. Teive
To estimate the prevalence of mutations in the PARK 2 or PARK 8 genes and characterize their phenotypes in a Brazilian cohort of early-onset Parkinsonism (EOP).
Recurrent Facial Baroparesis Occurring on Commercial Flights in The United States
William S Baek*
Facial baroparesis was first described in 1985 and refers to transient facial neurapraxia due to barotrauma. We report a case of recurrent facial baroparesis occurring during domestic flights.
CMT1A and T2DM versus CMT1A Alone: A Retrospective Comparison of Nerve Conduction Values and Terminal Latency Index
Andrew Lavigne and Steven K. Baker
To investigate the effects of concurrent Charcot-Marie-Tooth type 1A (CMT1A) and type 2 Diabetes mellitus (T2DM) on median nerve conduction parameters and terminal latency index.
Anemia and Cholesterol Level are Independently Associated with Anxiety and Depression
Anna G. Polunina*, Renat G. Akzhigitov, Alexander A. Yakovlev ,Anna A. Gudkova, Alla B. Guekht, Elena V. Smirnova,Natalia V. Gulyaeva
Depression and anxiety are multifactorial neuropsychiatric conditions characterized by intensive negative emotionality along with autonomic and neuroendocrine dysfunction.
Envisioning PACAP-Based Therapy for Alzheimer’s Disease
Pengcheng Han*, Jiong Shi, Mary T. Lucero
Alzheimer’s disease (AD) is the most common cause of dementia in elderly adults. With the growing number of people living to an older age, there is an urgency to better understand elements of the pathogenic pathway, discover agents that target these elements, and establish their roles in the treatment and prevention of AD.