Volume 2 Issue 3
Frontal Executive Functions in Medication Overuse Headache
Hüseyin Alparslan Sahin, Yakup Türkel, Esen Ozgan Sahin, Taner Özbenli
Migraine is the second most common cause of the primary headache after tension-type headache. It is characterized by generally unilateral attacks lasting 4-72 hours, presenting as throbbing headaches. It is unclear whether the cognitive impairment is a clinical feature of migraine. Many migraine patients report subjective cognitive impairments such as forgetfulness, inattentiveness and psychomotor tiredness.
Primary Lateral Sclerosis/Stiff Person Syndrome with a Response to Intravenous Immunoglobulin
Michael T Flannery*, Deborah Humphrey
Primary Lateral Sclerosis is a sister disease of ALS whose differences focus on the predominance of upper motor neuron findings with very little to no lower motor neuron findings. Our patient presented initially with spasticity predominately of the lower extremities with UMN findings of hyperreflexia in the patellar reflexes and an abnormal Babinski on the left. Eventually, the patient developed intermittent proximal spasms and increased spinal stiffness leading to decreased range of motion and mobility. At this time, the patient also had the presence of anti-Glutamic acid decarboxylase (GAD) antibodies which can be seen in 60% of patients with Stiff Person Syndrome.
The Case of a Metastatic Ductal Cell Carcinoma Followed by Mitoxantrone Use a Case Report
Masoud Ghiasian*, Sahar Moradee, Amir Zebarjadian
Multiple Sclerosis is a chronic inflammatory demyelinating disease of the CNS of an unknown cause. The course is extremely variable. After a number of years, there is an increasing tendency for patients to enter the phase of Slow Steadiness or Fluctuating Deterioration of neurologic function (Secondary Progressive). Secondary Progressive MS is more difficult to treat than relapsing and remitting form of the disease. At this step, one of the treatments is Mitoxantrone.
Orexin Receptor Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache
Masakazu Ishii*, Masaaki Ishibashi, Hirotaka Katoh
Patients with migraine disease are known to be complicated with medication overuse headache. Although it has been shown that orexin-1 receptor (HCRTR1, rs2271933) and orexin-2 receptor (HCRTR2, rs2653349) gene polymorphisms are contributed the pathophysiology of migraine, the relationship between these polymorphisms and medication overuse headache (MOH) is unknown. Therefore, we hypothesized that HCRTR1 and HCRTR2 gene polymorphisms may modify the aggravation of migraines due to medication overuse.